It takes two remotes to control either of our two TV sets. I gave up on universal remotes years ago. They were a bitch to program and never really worked after you did.
But I’m giving it one more try on the strength of a recommendation by George. The Harmony Remote by Logitech interfaces with your computer via USB. You hit the Harmony website to identify all of your components (by model number). The Harmony is programmed accordingly. Stay tuned.